Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.

@article{Nagane1998DrugRO,
  title={Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.},
  author={Motoo Nagane and Alexander Levitzki and A Amatzia Gazit and Webster K Cavenee and H. J. Huang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 10},
  pages={5724-9}
}
Alterations of the epidermal growth factor receptor (EGFR) gene occur frequently in human malignant gliomas. The most common of these is deletion of exons 2-7, resulting in truncation of the extracellular domain (DeltaEGFR or EGFRvIII), which occurs in a large fraction of de novo malignant gliomas (but not in progressive tumors or those lacking p53 function) and enhances tumorigenicity, in part by decreasing apoptosis through up-regulation of Bcl-XL. Here, we demonstrate that the DeltaEGFR… CONTINUE READING

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Nagane et al

  • C. M. Tsai, A. Levitzki, +6 authors 1068–1074. Medical Sciences
  • Proc. Natl. Acad. Sci. USA 95
  • 1998
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