Drug resistance of HIV-1 protease against JE-2147: I47V mutation investigated by molecular dynamics simulation.

@article{Bandyopadhyay2006DrugRO,
  title={Drug resistance of HIV-1 protease against JE-2147: I47V mutation investigated by molecular dynamics simulation.},
  author={Pradipta Bandyopadhyay and Biswa Ranjan Meher},
  journal={Chemical biology & drug design},
  year={2006},
  volume={67 2},
  pages={155-61}
}
Anti-retroviral therapies for acquired immunodeficiency syndrome (AIDS) patients are at risk because of drug resistance that has been identified with a number of currently marketed drugs. HIV-1 protease (HIV-pr), a well-validated AIDS therapeutic target, undergoes various mutations leading to resistance such existing drugs. However, the molecular basis of drug resistance of HIV-pr is still not fully understood. JE-2147, an experimental inhibitor of HIV-pr, shows a resistance profile different… CONTINUE READING

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