Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race.

@article{Vanaerschot2014DrugRI,
  title={Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race.},
  author={Manu Vanaerschot and Silvie Huijben and Frederik Van den Broeck and J M Dujardin},
  journal={FEMS microbiology reviews},
  year={2014},
  volume={38 1},
  pages={41-55}
}
Drug-resistant pathogens emerge faster than new drugs come out of drug discovery pipelines. Current and future drug options should therefore be better protected, requiring a clear understanding of the factors that contribute to the natural history of drug resistance. Although many of these factors are relatively well understood for most bacteria, this proves to be more complex for vectorborne parasites. In this review, we discuss considering three key models (Plasmodium, Leishmania and… CONTINUE READING