Drug resistance in metastatic castration-resistant prostate cancer

@article{eruga2011DrugRI,
  title={Drug resistance in metastatic castration-resistant prostate cancer},
  author={Bo{\vs}tjan {\vS}eruga and Alberto Oca{\~n}a and Ian F. Tannock},
  journal={Nature Reviews Clinical Oncology},
  year={2011},
  volume={8},
  pages={12-23}
}
Docetaxel in combination with prednisone is the standard of care in men with symptomatic castration-resistant prostate cancer (CRPC). However, a substantial proportion of men with CRPC do not benefit from docetaxel or other systemic therapy and those who do benefit invariably progress and die of (or with) prostate cancer. Resistance to chemotherapy in metastatic CRPC is a result of cellular mechanisms of drug resistance intrinsic to prostate cancer and general mechanisms common to different… 

Emerging targets to monitor and overcome docetaxel resistance in castration resistant prostate cancer (review).

The molecules associated with resistance, such as the molecular chaperones heat shock proteins and clusterin, and the cytokines interleukin-6 (IL-6) and the divergent member of the tumor growth factor family MIC-1 (macrophage inhibitory cytokine-1 also named GDF-15) are discussed, and their interest as blood-based markers to monitor docetaxel resistance.

Current Treatment Modalities Targeting Tumor Microenvironment in Castration-Resistant Prostate Cancer.

The current state of the literature regarding treatment modalities is reviewed, focusing on the treatment recommendations per the American Urological Association (AUA), recent clinical trials, and their limitations.

Chemotherapy-based treatment for castration-resistant prostate cancer.

  • B. ŠerugaI. Tannock
  • Medicine
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2011
With the approval of less toxic hormonal agents in the setting of docetaxel-resistant mCRPC, clinicians will have an opportunity to balance benefits and harms of new agents in an individual patient and may be able to use different agents in sequence.

Overcoming docetaxel resistance in prostate cancer: a perspective review

  • C. Hwang
  • Medicine, Biology
    Therapeutic advances in medical oncology
  • 2012
Recent therapeutic advances in metastatic castrate-resistant prostate cancer as well as ongoing clinical trials are discussed, including several new drugs that are effective after docetaxel failure, dramatically changing the therapeutic landscape for these patients.

Androgen Receptor Signaling in Castration Resistant Prostate Cancer

The mechanisms through which the AR signaling axis promotes resistance to androgen-deprivation therapy and drives progression of castration resistant prostate cancer (CRPC) are reviewed.

Novel therapeutic strategies for metastatic prostate cancer in the post-docetaxel setting.

The cell-based immunotherapy sipuleucel-T produces longer OS times in chemotherapy-naïve patients, whereas the androgen biosynthesis inhibitor abiraterone acetate results in longerOS times following docetaxel, envisioned that these agents will change the standard of care for patients with metastatic CRPC.

Overcoming Drug Resistance and Treating Advanced Prostate Cancer

This review will present recent findings on the molecular and cellular pathways that are responsible for bone metastasis of PCa, and address several novel mechanisms with a focus on the role of bone and bone marrow microenvironment in promoting PCa metastasis.

Treatment patterns and clinical efectiveness in metastatic castrate resistant prostate cancer after frst-line docetaxel

Patients with castrateresistant prostate cancer (mCRPC) who have a progression after docetaxel therapy may receive rechallenge with docetAXel or be considered for other subsequent therapies, as well as those patients who can tolerate taxane therapy.
...

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