Drug-resistance in central nervous system tumors: from the traditional cell-resistance model to the genetically driven approaches on therapy.

@article{Valera2007DrugresistanceIC,
  title={Drug-resistance in central nervous system tumors: from the traditional cell-resistance model to the genetically driven approaches on therapy.},
  author={Elvis Terci Valera and Helio Rubens Machado and Carlos Alberto Scrideli and Agda Karina Brodoloni Lucio-Eterovic and Lu{\'i}s Gonzaga Tone},
  journal={Current pharmaceutical biotechnology},
  year={2007},
  volume={8 2},
  pages={105-13}
}
The advances in the cure rates observed in the oncology field in the past decades were not fully assembled by primary brain tumors. In this heterogeneous group of diseases, resistance to either chemotherapy or radiotherapy still is a major problem to be addressed. Several genetic and epigenetic events may directly influence the response to treatment in… CONTINUE READING