Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

  title={Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission},
  author={Ann Bishop and B Birkett},
  pages={125 - 137}
1. Attempts, made over a period of more than 6 months, to produce a strain of Plasmodium gallinaceum resistant to mepacrine failed. 2. A strain of P. gallinaceum resistant to daily doses of 0·08 mg./20 g. of pamaquin was obtained after approximately 8 months' treatment with the drug. 3. A strain of P. gallinaceum resistant to the maximum dose of paludrine which the chicks would tolerate (1·0 mg./20 g. twice daily) was obtained after 4½ months' treatment with gradually increasing doses of the… 

The development of resistance to metachloridine in Plasmodium gallinaceum in Chicks

1. An increase in resistance to metachloridine of more than 100-fold was obtained within a few weeks in a strain of Plasmodium gallinaceum treated with gradually increasing doses of the drug and

Latent infections in avian malaria in relation to the production of drug-resistance

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Resistance to primaquine in Plasmodium gallinaceum, and the problem of resistance to quinoline compounds in malaria parasites

A tenfold enhancement of resistance to primaquine was obtained by maintaining a strain of Plasmodium gallinaceum in a state of acute infection by serial passage of infected blood through young chicks

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The following account describes the development of a primaquine-resistant strain of P. gallinaceum, its stability, and the effect of other antimalarial drugs upon it; it also describes attempts to produce resistance to chloroquine in this species and discusses the general problem of resistance to aminoquinolines in malaria parasites.

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A fourfold enhancement of resistance to diamino-diphenylsulphone has been produced over a period of 15 months in strain A of P. gallinaceum by subjecting the strain, maintained in a state of patent

Pamaquin Resistance in a Strain of Plasmodium gallinaceum and its relationship to Other antimalarial Drugs

A four- to eight-fold increase in resistance to pamaquin has been developed in a strain of Plasmodium gallinaceum in chicks, and an appreciable loss in resistance was observed after it had been maintained in the absence of the drug for a period of 6 months.

Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds

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A strain of monkey malaria (Plasmodium cynomolgi) made resistant to proguanil (paludrine).

Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide

The sulphanilamide-resistant strain was resistant to paludrine over the whole range of doses tolerated by the host; it also proved to be resistant to sulphathiazole, sulphapyridine and sulpha-diazine, though the degree of resistance shown was much slighter than to Paludrine.

The chemotherapy of Plasmodium berghei. I. Resistance to drugs.

1. Strains of P. berghei resistant to sulphadiazine, pyrimethamine, and methylene blue were produced by treating acute infections with low doses of drug. 2. The strain resistant to methylene blue was



The response of blood-inoculated and sporozoite-induced infections of Plasmodium relictum to drugs

The possible mechanisms by which blood-inoculated infections are eradicated, or resist eradication, are discussed, and parasites devoid of pigment appear in the erythrocytes of the peripheral blood.

Prophylactic and Curative Effects of Certain Sulfonamide Compounds on Exoerythroeytic Stages in Plasmodium Gallinaceum Malaria.

The fact that exoerythrocytic stages of Plasmodium gallinaceum respond so readily to some of the sulfonamide compounds and yet are totally refractory to quinine or atebrin furnish another lead in the study of malarial chemotherapy.

Effects of Paludrine and Other Antimalarials

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This man walks well and is free from pain, excepting a slight cramp of the right calf if he hurries, and his general condition i, greatly improved, three months after the operation.

Acquired Resistance to Paludrine in Plasmodium Gallinaceum

Acquired Resistance and Persistence after Passage through the Mosquito