Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission

@article{Bishop1948DrugresistanceIP,
  title={Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission},
  author={Ann Bishop and B Birkett},
  journal={Parasitology},
  year={1948},
  volume={39},
  pages={125 - 137}
}
1. Attempts, made over a period of more than 6 months, to produce a strain of Plasmodium gallinaceum resistant to mepacrine failed. 2. A strain of P. gallinaceum resistant to daily doses of 0·08 mg./20 g. of pamaquin was obtained after approximately 8 months' treatment with the drug. 3. A strain of P. gallinaceum resistant to the maximum dose of paludrine which the chicks would tolerate (1·0 mg./20 g. twice daily) was obtained after 4½ months' treatment with gradually increasing doses of the… 

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References

SHOWING 1-10 OF 21 REFERENCES

The response of blood-inoculated and sporozoite-induced infections of Plasmodium relictum to drugs

The possible mechanisms by which blood-inoculated infections are eradicated, or resist eradication, are discussed, and parasites devoid of pigment appear in the erythrocytes of the peripheral blood.

Prophylactic and Curative Effects of Certain Sulfonamide Compounds on Exoerythroeytic Stages in Plasmodium Gallinaceum Malaria.

The fact that exoerythrocytic stages of Plasmodium gallinaceum respond so readily to some of the sulfonamide compounds and yet are totally refractory to quinine or atebrin furnish another lead in the study of malarial chemotherapy.

Effects of Paludrine and Other Antimalarials

THE facility with which pathogenic protozoa and A bacteria may acquire resistance to therapeutic agents, as a result of non-curative treatment of infections by these pathogens, is of profound

QUANTITATIVE STUDIES OF SULFONAMIDE RESISTANCE

It is postulated that, despite reports to the contrary, all organisms susceptible to the bacteriostatic action of the sulfonamides are capable of becoming resistant to all of the sulfur-based drugs.

EFFECT OF PASSAGE THROUGH GLOSSINA on the RESISTANCE OF A TRYPARSAMIDE-FAST TRYPANOSOME *

This man walks well and is free from pain, excepting a slight cramp of the right calf if he hurries, and his general condition i, greatly improved, three months after the operation.

Acquired Resistance to Paludrine in Plasmodium Gallinaceum

Acquired Resistance and Persistence after Passage through the Mosquito