Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia.

@article{Wilson1989DrugRI,
  title={Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia.},
  author={Roger E. Wilson and Peter C. Keng and Robert M. Sutherland},
  journal={Journal of the National Cancer Institute},
  year={1989},
  volume={81 16},
  pages={1235-40}
}
Chinese hamster ovary cells exposed to hypoxia developed an 80-fold resistance to a subsequent 1-hour exposure to doxorubicin (ADR) in air. Recovery in air before drug exposure resulted in loss of resistance. Cells exposed to hypoxia for 20 hours followed by a 15-hour recovery were still twofold to threefold more resistant than aerobic cells to a short… CONTINUE READING