Drug resistance: Passing on protection

  • J. Owens
  • Published 2005 in Nature Reviews Drug Discovery

Abstract

NATURE REVIEWS | DRUG DISCOVERY VOLUME 4 | MARCH 2005 | 191 The overexpression of P-glycoprotein (P-gp) is well established as a cause of multidrug resistance in cancer cells. However, it now seems that drugresistant cells can physically pass this protein on to drug-sensitive cells in vitro and in vivo, enabling the recipient cells to survive potentially… (More)
DOI: 10.1038/nrd1668

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