Drug resistance: Hit where it hurts

Abstract

NATURE REVIEWS | DRUG DISCOVERY VOLUME 1 | FEBRUARY 2002 | 97 Protease inhibitors are a key part of many treatment regimes for AIDS, but rapid evolution of resistance can limit their effectiveness. Using crystal structures of human immunodeficiency virus (HIV) protease and its complexes with inhibitors, in combination with clinical resistance data, Wei Wang… (More)
DOI: 10.1038/nrd735

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