Drug repositioning and pharmacophore identification in the discovery of hookworm MIF inhibitors.

Abstract

The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new pharmacophores. Hookworms are blood-feeding, intestinal nematode parasites that infect up to 600 million people worldwide. Vaccination with recombinant Ancylostoma ceylanicum macrophage migration inhibitory factor (rAceMIF… (More)
DOI: 10.1016/j.chembiol.2011.07.011

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