Drug releasing behavior of hybrid micelles containing polypeptide triblock copolymer.

Abstract

We report a new type of hybrid polymeric micelles for drug delivery applications. These micelles consist of PLGA (PLGA: poly(l-glutamic acid)) and PEG (PEG: polyethylene glycol) mixed corona chains. In acidic condition, PLGA undergoes a transformation from water-soluble random coils to water-insoluble alpha-helix, leading to microphase separation in micelle… (More)
DOI: 10.1016/j.biomaterials.2008.09.010

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