Drug release from a multiparticulate pellet system.

  title={Drug release from a multiparticulate pellet system.},
  author={K R Zimm and Joseph B. Schwartz and Robert E. O'Connor},
  journal={Pharmaceutical development and technology},
  volume={1 1},
Multiparticulate pellet systems are used as both immediate and modified release dosage forms. Previous work has classified uncoated pellet systems prepared from microcrystalline cellulose as an inert matrix. The Higuchi square root of time equation, derived to describe drug release from a single planar system, is the accepted method to evaluate drug release from both planar and spherical heterogeneous inert granular matrices. A second equation of interest, the Higuchi cubic equation, was… CONTINUE READING

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