Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C.

  title={Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C.},
  author={M. Amin F. Zarandi and Payam Zahedi and Iraj Rezaeian and Alireza Salehpour and Mehdi Gholami and Behrooz Motealleh},
  journal={IET nanobiotechnology},
  volume={9 4},
In this work, N, O-carboxymethyl chitosan (CMCS) samples from virgin chitosan (CS) were synthesised and CMCS/polyethylene oxide (PEO) (50/50) blend nanofibrous samples were successfully electrospun from their aqueous solution. The electrospinning conditions to achieve smooth and fine diameter nanofibrous mats were optimised via D-optimal design approach. Afterwards, vitamin C and phenytoin sodium (PHT-Na) were added to these samples for producing wound dressing materials. H-nuclear magnetic… 

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