Drug-related hepatotoxicity.

  title={Drug-related hepatotoxicity.},
  author={V. Navarro and J. Senior},
  journal={The New England journal of medicine},
  volume={354 7},
  • V. Navarro, J. Senior
  • Published 2006
  • Medicine
  • The New England journal of medicine
  • Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients are exposed, toxic effects that are very infrequent may emerge. This review explains the difficulties in identifying the cause of hepatotoxic effects in such situations and provides clinical guidance with regard to the detection, evaluation, and possible prevention of drug-related hepatotoxicity.