Drug-related hepatotoxicity.

@article{Navarro2006DrugrelatedH,
  title={Drug-related hepatotoxicity.},
  author={Victor J. Navarro and John R. Senior},
  journal={The New England journal of medicine},
  year={2006},
  volume={354 7},
  pages={
          731-9
        }
}
Given its rarity, drug-related hepatotoxicity may not be seen during the initial clinical trials of a new medication. After approval, when many more patients are exposed, toxic effects that are very infrequent may emerge. This review explains the difficulties in identifying the cause of hepatotoxic effects in such situations and provides clinical guidance with regard to the detection, evaluation, and possible prevention of drug-related hepatotoxicity. 

Citations

Publications citing this paper.
SHOWING 1-10 OF 473 CITATIONS, ESTIMATED 71% COVERAGE

Drug-induced liver injury in Oncology

  • Alejandro D. Ricart
  • Medicine
  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2017
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Inhibition of bile canalicular network formation in rat sandwich cultured hepatocytes by drugs associated with risk of severe liver injury.

VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Long-term hepatic safety of ambrisentan in patients with pulmonary arterial hypertension.

VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Analysis of GSTM 1 Deletion on Adult Pulmonary Tuberculosis Patients

VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 24 Highly Influenced Citations

  • Averaged 38 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 59 REFERENCES

Hepatotoxicity through the years: impact on the FDA

  • RJ Temple
  • (Accessed January
  • 2006

Drug-induced acute liver failure in the United State 2005: results from the U.S. Acute Liver Failure Study Group. FDA-PhRMA-AASLD Hepatotoxicity Steering Committee meeting

  • WM Lee
  • 2005