Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development.


It is generally accepted that there is neither a well-defined nor a consistent link between the formation of drug-protein adducts and organ toxicity. Because the potential does exist, however, for these processes to be causally related, the general strategy at Merck Research Laboratories has been to minimize reactive metabolite formation to the extent… (More)


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