Drug permeability profiling using cell-free permeation tools: Overview and applications.

@article{Berben2018DrugPP,
  title={Drug permeability profiling using cell-free permeation tools: Overview and applications.},
  author={Philippe Berben and Annette Bauer-Brandl and Matthias Brandl and Bernard Faller and G{\o}ril Eide Flaten and Ann-Christin Jacobsen and Joachim Brouwers and Patrick Augustijns},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2018},
  volume={119},
  pages={
          219-233
        }
}
Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption without the disadvantages associated with cell- or tissue-based permeability profiling. Depending on the composition of the barrier, cell-free permeation systems are classified into two classes including (i) biomimetic barriers which are constructed from (phospho)lipids and (ii) non-biomimetic barriers containing dialysis membranes. This… CONTINUE READING
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