Drug metabolite profiling and identification by high-resolution mass spectrometry.

@article{Zhu2011DrugMP,
  title={Drug metabolite profiling and identification by high-resolution mass spectrometry.},
  author={Mingshe Zhu and Haiying Zhang and W Griffith Humphreys},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 29},
  pages={25419-25}
}
Mass spectrometry plays a key role in drug metabolite identification, an integral part of drug discovery and development. The development of high-resolution (HR) MS instrumentation with improved accuracy and stability, along with new data processing techniques, has improved the quality and productivity of metabolite identification processes. In this minireview, HR-MS-based targeted and non-targeted acquisition methods and data mining techniques (e.g. mass defect, product ion, and isotope… CONTINUE READING

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