Drug metabolism by flavin-containing monooxygenases of human and mouse.

  title={Drug metabolism by flavin-containing monooxygenases of human and mouse.},
  author={Ian R. Phillips and Elizabeth A Shephard},
  journal={Expert opinion on drug metabolism & toxicology},
  volume={13 2},
INTRODUCTION Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse. We describe FMO genes and proteins of human and mouse; the catalytic mechanism of FMOs and their significance for drug metabolism; differences between FMOs and CYPs; factors contributing to potential underestimation of the contribution of FMOs to drug metabolism; the developmental and tissue-specific expression… CONTINUE READING
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