Drug metabolism by cytochromes P450 in the liver and small bowel.

  title={Drug metabolism by cytochromes P450 in the liver and small bowel.},
  author={Paul B Watkins},
  journal={Gastroenterology clinics of North America},
  volume={21 3},
  • Paul B Watkins
  • Published 1992 in Gastroenterology clinics of North America
Most drugs used clinically are metabolized by cytochromes P450. These enzymes have been best characterized in the liver, where it appears the major drug-metabolizing P450s belong to three gene families. There appear to be remarkable differences among patients in the catalytic activity of each of the P450s within these three families, and it is increasingly evident that this heterogeneity accounts, at least in part, for differences among patients in response to many medications. In addition, it… CONTINUE READING
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