Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5.

@article{Kaspera2011DrugMB,
  title={Drug metabolism by CYP2C8.3 is determined by substrate dependent interactions with cytochrome P450 reductase and cytochrome b5.},
  author={R{\"u}diger Kaspera and Suresh Babu Naraharisetti and Eric A. Evangelista and Kristin D. Marciante and Bruce M. Psaty and Rheem A. Totah},
  journal={Biochemical pharmacology},
  year={2011},
  volume={82 6},
  pages={681-91}
}
Genetic polymorphisms in CYP2C8 can influence the metabolism of important therapeutic agents and cause interindividual variation in drug response and toxicity. The significance of the variant CYP2C8*3 has been controversial with reports of higher in vivo but lower in vitro activity compared to CYP2C8*1. In this study, the contribution of the redox partners cytochrome P450 reductase (CPR) and cytochrome b5 to the substrate dependent activity of CYP2C8.3 (R139K, K399R) was investigated in human… CONTINUE READING

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