Drug-like properties and the causes of poor solubility and poor permeability.

  title={Drug-like properties and the causes of poor solubility and poor permeability.},
  author={Christopher A. Lipinski},
  journal={Journal of pharmacological and toxicological methods},
  volume={44 1},
  • C. Lipinski
  • Published 2000
  • Chemistry, Medicine
  • Journal of pharmacological and toxicological methods
There are currently about 10000 drug-like compounds. These are sparsely, rather than uniformly, distributed through chemistry space. True diversity does not exist in experimental combinatorial chemistry screening libraries. Absorption, distribution, metabolism, and excretion (ADME) and chemical reactivity-related toxicity is low, while biological receptor activity is higher dimensional in chemistry space, and this is partly explainable by evolutionary pressures on ADME to deal with endobiotics… Expand
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