• Medicine
• Published in
  American journal of health…
  2007
• DOI:10.2146/ajhp060414

Drug interactions with smoking.

@article{Kroon2007DrugIW,
  title={Drug interactions with smoking.},
  author={Lisa A. Kroon},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2007},
  volume={64 18},
  pages={
          1917-21
        }
}

• Lisa A. Kroon

PURPOSE The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed. SUMMARY Polycyclic aromatic hydrocarbons (PAHs) are some of the major lung carcinogens found in tobacco smoke. PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The… CONTINUE READING

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