Drug interactions with smoking.
@article{Kroon2007DrugIW, title={Drug interactions with smoking.}, author={Lisa Kroon}, journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists}, year={2007}, volume={64 18}, pages={ 1917-21 } }
PURPOSE
The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed.
SUMMARY
Polycyclic aromatic hydrocarbons (PAHs) are some of the major lung carcinogens found in tobacco smoke. PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The…
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References
SHOWING 1-10 OF 36 REFERENCES
Drug Interactions with Tobacco Smoking
- Medicine, BiologyClinical pharmacokinetics
- 1999
The laboratory has found in an intraindividual study that cigarette smoking significantly enhances CYP2E1 activity as measured by the clearance of chlorzoxazone, and the impact of cigarette smoking needs to be considered in planning and assessing responses to drug therapy.
Metabolism and Disposition Kinetics of Nicotine
- Biology, MedicinePharmacological Reviews
- 2005
Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed.
Psychopharmacology: Atypical Antipsychotic Dosing: The Effect of Smoking and Caffeine
- Medicine, Psychology
- 2004
The case reports of clozapine’s toxicity after smoking cessation suggest that the inductive effects of smoking take at least two to four weeks to disappear, and pharmacologic support of the relevance of smoking‘s induction effects comes from caffeine intake studies.
Role of the Smoking-Induced Cytochrome P450 (CYP)1A2 and Polymorphic CYP2D6 in Steady-State Concentration of Olanzapine
- Medicine, PsychologyJournal of clinical psychopharmacology
- 2003
Smoking-induced increased CYP1A2 activity significantly diminished plasma olanzapine concentrations and the antipsychotic effect of the drug, and such inhibition can contribute to adverse drug interactions.
Cigarette abstinence, nicotine gum, and theophylline disposition.
- MedicineAnnals of internal medicine
- 1987
The data indicate that at least partial normalization of the enzyme-inducing effects of smoking can be seen after brief cigarette abstinence, which means that smokers who are taking theophylline chronically will need to be reduced by one fourth to one third after brief tobacco abstinence.
Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age
- Medicine, PsychologyPsychopharmacology
- 2004
A considerable variation of clozapine plasma levels at a given dose depending on a number of factors should be taken into consideration for efficient therapy with the lowest possible dose.
Epidemiology of Oral Contraceptives and Cardiovascular Disease
- MedicineAnnals of Internal Medicine
- 1998
The current use of oral contraceptives increases risk for myocardial infarction, but most of the excess risk is attributable to an interaction with cigarette smoking.
The role of nicotine in smoking-related cardiovascular disease.
- Biology, MedicinePreventive medicine
- 1997
Clinical studies of pipe smokers and people using transdermal nicotine support the idea that toxins other than nicotine are the most important causes of acute cardiovascular events, and the dose response for cardiovascular events of nicotine appears to be flat, suggesting that if nicotine is involved, adverse effects might be seen with relatively low-level cigarette exposures.
Effects of the CYP 2D6 Genotype and Cigarette Smoking on the Steady‐State Plasma Concentrations of Fluvoxamine and Its Major Metabolite Fluvoxamino Acid in Japanese Depressed Patients
- Medicine, BiologyTherapeutic drug monitoring
- 2003
The present study suggests that the CYP 2D6 genotype and cigarette smoking have no major impact on the Css of FLV and FLA, though CYP 1D6 is involved in the demethylation ofFLV.
Quetiapine: preclinical studies, pharmacokinetics, drug interactions, and dosing.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2002
In animal models, imaging studies with positron emission tomography confirm significant differences between quetiapine and typical antipsychotics that may be indicative of their differences in mechanism of action and propensity for producing EPS.