Drug interactions with smoking.

@article{Kroon2007DrugIW,
  title={Drug interactions with smoking.},
  author={Lisa Kroon},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2007},
  volume={64 18},
  pages={
          1917-21
        }
}
  • L. Kroon
  • Published 15 September 2007
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed. SUMMARY Polycyclic aromatic hydrocarbons (PAHs) are some of the major lung carcinogens found in tobacco smoke. PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The… 
View on PubMed
rxforchange.ucsf.edu
288 Citations
Highly Influential Citations
13
Background Citations
97
Methods Citations
2
Results Citations
4

Figures from this paper

288 Citations

[Smoking and drug interactions].
TLDR
When planning smoking cessation or when a smoker is acutely hospitalized, the medication has to be screened and need for changes in dosages and measurements of drug concentrations to be evaluated.
Effects of Cigarette Smoking on Metabolism and Effectiveness of Systemic Therapy for Lung Cancer
TLDR
Systemic therapy for lung cancer has a narrow therapeutic index such that small changes in plasma concentrations or exposure in smokers may result in suboptimal therapy and poor outcomes.
A review of smoking cessation: potentially risky effects on prescribed medications.
TLDR
The effects of smoking cessation on drugs metabolised by CYP1A2 have been under-appreciated by health care providers and providers should carefully review prescribed drug regimens and adjust or monitor drugs whose metabolism is affected by smoking cessation.
Impact of smoking on metabolic changes and effectiveness of drugs used for lung cancer.
  • F. Perlík
  • Medicine
    Central European journal of public health
  • 2020
TLDR
The evaluated studies show that continued smoking after lung cancer diagnosis is related to poor prognosis, reduced survival, risk of second primary malignancies, and increased cancer recurrence.
Influence of tobacco smoke exposure on pharmacokinetics of ethyl alcohol in alcohol preferring and non-preferring rats.
Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy
TLDR
Smokers treated with docetaxel and paclitaxel have less neutropenia and leukopenia, but further research is warranted to elucidate this potential protective effect.
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2
TLDR
A different dosing strategy is required among smoking and nonsmoking patients, as smoking may not only induce CYP1A2, but may possibly also affect CYP2C19 and UGT1A3, and CYP3A4, which might be induced by tobacco smoke.
Impact of Smoking, Smoking Cessation, and Genetic Polymorphisms on CYP1A2 Activity and Inducibility
TLDR
The interindividual change in CYP1A2 activity after smoking cessation was determined and it was found that the individual change in activity ranged from 1.0‐fold (no change) to a 7.3‐fold decrease in activity.
Therapeutic Drug Monitoring of Second- and Third-Generation Antipsychotic Drugs—Influence of Smoking Behavior and Inflammation on Pharmacokinetics
TLDR
The following narrative review provides an overview of relevant literature regarding TDM in psychiatry, particularly in the context of second- and third-generation antipsychotic drugs, inflammation, and smoking behavior.
The effect of smoking on the plasma concentration of tricyclic antidepressants - a systematic review.
TLDR
There is a possibility that smoking affects the distribution of TCA metabolites, but this is probably not of clinical importance.
...
...

References

SHOWING 1-10 OF 39 REFERENCES
Metabolism and Disposition Kinetics of Nicotine
TLDR
Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed.
Psychopharmacology: Atypical Antipsychotic Dosing: The Effect of Smoking and Caffeine
TLDR
The case reports of clozapine’s toxicity after smoking cessation suggest that the inductive effects of smoking take at least two to four weeks to disappear, and pharmacologic support of the relevance of smoking‘s induction effects comes from caffeine intake studies.
Role of the Smoking-Induced Cytochrome P450 (CYP)1A2 and Polymorphic CYP2D6 in Steady-State Concentration of Olanzapine
TLDR
Smoking-induced increased CYP1A2 activity significantly diminished plasma olanzapine concentrations and the antipsychotic effect of the drug, and such inhibition can contribute to adverse drug interactions.
Cigarette abstinence, nicotine gum, and theophylline disposition.
TLDR
The data indicate that at least partial normalization of the enzyme-inducing effects of smoking can be seen after brief cigarette abstinence, which means that smokers who are taking theophylline chronically will need to be reduced by one fourth to one third after brief tobacco abstinence.
Dose-related plasma levels of clozapine: influence of smoking behaviour, sex and age
TLDR
A considerable variation of clozapine plasma levels at a given dose depending on a number of factors should be taken into consideration for efficient therapy with the lowest possible dose.
Epidemiology of Oral Contraceptives and Cardiovascular Disease
TLDR
The current use of oral contraceptives increases risk for myocardial infarction, but most of the excess risk is attributable to an interaction with cigarette smoking.
The role of nicotine in smoking-related cardiovascular disease.
TLDR
Clinical studies of pipe smokers and people using transdermal nicotine support the idea that toxins other than nicotine are the most important causes of acute cardiovascular events, and the dose response for cardiovascular events of nicotine appears to be flat, suggesting that if nicotine is involved, adverse effects might be seen with relatively low-level cigarette exposures.
Effects of the CYP 2D6 Genotype and Cigarette Smoking on the Steady‐State Plasma Concentrations of Fluvoxamine and Its Major Metabolite Fluvoxamino Acid in Japanese Depressed Patients
TLDR
The present study suggests that the CYP 2D6 genotype and cigarette smoking have no major impact on the Css of FLV and FLA, though CYP 1D6 is involved in the demethylation ofFLV.
Quetiapine: preclinical studies, pharmacokinetics, drug interactions, and dosing.
TLDR
In animal models, imaging studies with positron emission tomography confirm significant differences between quetiapine and typical antipsychotics that may be indicative of their differences in mechanism of action and propensity for producing EPS.
CYP1A2 Activity as Measured by a Caffeine Test Predicts Clozapine and Active Metabolite Norclozapine Steady-State Concentration in Patients With Schizophrenia
TLDR
CYP1A2 is one of the important contributors to disposition of clozapine during multiple-dose treatment and appears to be subsequent to the formation of norclozAPine, hitherto less recognized quantitatively important alternate disposition routes, or both.
...
...