Drug interactions with smoking.

@article{Kroon2007DrugIW,
  title={Drug interactions with smoking.},
  author={L. Kroon},
  journal={American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists},
  year={2007},
  volume={64 18},
  pages={
          1917-21
        }
}
  • L. Kroon
  • Published 2007
  • Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
PURPOSE The mechanisms for drug interactions with smoking and clinically significant pharmacokinetic and pharmacodynamic drug interactions with smoking are reviewed. SUMMARY Polycyclic aromatic hydrocarbons (PAHs) are some of the major lung carcinogens found in tobacco smoke. PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. After a person quits smoking, an important consideration is how quickly the induction of CYP1A2 dissipates. The… Expand
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265 Citations
Highly Influential Citations
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Methods Citations
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265 Citations

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Citation Type

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TLDR
When planning smoking cessation or when a smoker is acutely hospitalized, the medication has to be screened and need for changes in dosages and measurements of drug concentrations to be evaluated. Expand
A review of smoking cessation: potentially risky effects on prescribed medications.
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The effects of smoking cessation on drugs metabolised by CYP1A2 have been under-appreciated by health care providers and providers should carefully review prescribed drug regimens and adjust or monitor drugs whose metabolism is affected by smoking cessation. Expand
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Systemic therapy for lung cancer has a narrow therapeutic index such that small changes in plasma concentrations or exposure in smokers may result in suboptimal therapy and poor outcomes. Expand
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  • F. Perlík
  • Medicine
  • Central European journal of public health
  • 2020
TLDR
The evaluated studies show that continued smoking after lung cancer diagnosis is related to poor prognosis, reduced survival, risk of second primary malignancies, and increased cancer recurrence. Expand
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TLDR
Ethanol levels were lower in animals exposed to tobacco Smoke compared to rats receiving this xenobiotic, without a prior exposure to tobacco smoke, and lower values of the studied pharmacokinetic parameters were observed in the alcohol preferring males compared to the non-alcohol preferring rats. Expand
Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy
TLDR
Smokers treated with docetaxel and paclitaxel have less neutropenia and leukopenia, but further research is warranted to elucidate this potential protective effect. Expand
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2
TLDR
A different dosing strategy is required among smoking and nonsmoking patients, as smoking may not only induce CYP1A2, but may possibly also affect CYP2C19 and UGT1A3, and CYP3A4, which might be induced by tobacco smoke. Expand
Impact of Smoking, Smoking Cessation, and Genetic Polymorphisms on CYP1A2 Activity and Inducibility
TLDR
The interindividual change in CYP1A2 activity after smoking cessation was determined and it was found that the individual change in activity ranged from 1.0‐fold (no change) to a 7.3‐fold decrease in activity. Expand
The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in Brazilian patients.
TLDR
The anti-TB drugs interactions with smoking on hepatotoxicity, as well as the NAT2 phenotype, may require to adjust therapeutic regimen dosages or alarm in case of adverse event developments. Expand
Therapeutic Drug Monitoring of Second- and Third-Generation Antipsychotic Drugs—Influence of Smoking Behavior and Inflammation on Pharmacokinetics
TLDR
The following narrative review provides an overview of relevant literature regarding TDM in psychiatry, particularly in the context of second- and third-generation antipsychotic drugs, inflammation, and smoking behavior. Expand
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TLDR
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TLDR
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TLDR
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