Drug interactions with quinolones.

  title={Drug interactions with quinolones.},
  author={Rob Janknegt},
  journal={The Journal of antimicrobial chemotherapy},
  volume={26 Suppl D},
  • Rob Janknegt
  • Published in The Journal of antimicrobial chemotherapy 1990
The pharmacodynamic and pharmacokinetic drug interactions and pharmaceutical compatibilities of fluoroquinolones are reviewed. Incompatibilities are observed between quinolones and penicillins such as flucloxacillin and amoxicillin and with clindamycin when mixed in an administration set. Fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, inhibit the metabolic clearance of theophylline and caffeine. It is advisable to use non-interacting quinolones such… CONTINUE READING


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