Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence.

  • Angelo A Izzo
  • Published 2004 in
    International journal of clinical pharmacology…


St. John's Wort (SJW, Hypericum perforatum) is effective in mild-to-moderate depression. As a monotherapy, SJW has an encouraging safety profile. However, numerous reports indicate the possibility of important interactions with prescribed drugs. SJW has been shown to lower the plasma concentration (and/or the pharmacological effect) of a number of drugs… (More)


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