Drug interactions between chemotherapeutic regimens and antiepileptics.
@article{Yap2008DrugIB, title={Drug interactions between chemotherapeutic regimens and antiepileptics.}, author={Kevin Yi-Lwern Yap and Wai Keung Chui and Alexandre Chan}, journal={Clinical therapeutics}, year={2008}, volume={30 8}, pages={ 1385-407 } }
137 Citations
Clinically relevant drug interactions between anticancer drugs and psychotropic agents.
- Psychology, MedicineEuropean journal of cancer care
- 2011
Clinicians should be vigilant when psychotropics are prescribed concurrently with ACDs, as well as to ensure adequate chemotherapeutic and psychotropic coverage, to avoid toxicity in the patient.
Drug-Drug Interactions between Oral Antiepileptics and Oral Anticancer Drugs: Implications to Clinicians
- MedicineEuropean Neurology
- 2010
There is a relatively low prevalence of AED-oral ACD combined exposure in the population sampled; however, the combined exposure is long enough to produce clinically important DDI effects.
Potential Drug Interactions Between Psychotropics and Intravenous Chemotherapeutics Used by Patients With Cancer
- Medicine, PsychologyThe Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians
- 2022
It was shown that a considerable percentage of patients undergoing intravenous chemotherapy are at risk of pharmacological interaction with psychotropic drugs, and it is essential that the oncologist considers all psychotrop drugs and other drugs used by patients in order to avoid drug-drug interactions.
Evaluation of the systemic and therapeutic repercussions caused by drug interactions in oncology patients.
- Medicine, BiologyRevista da Associacao Medica Brasileira
- 2019
In the present study, drug interactions were frequent, including serious interactions with a potential increase in morbidity and mortality, and it is necessary for oncologists to draw up a therapeutic plan considering potential interactions between prescribed chemotherapy and current medications in use by patients.
Clinically-relevant chemotherapy interactions with complementary and alternative medicines in patients with cancer
- Medicine, Biology
- 2010
Clinicians should be vigilant when treating cancer patients who take CAMs with concurrent chemotherapy since they face a high risk of HDIs, which can be minimized or avoided by selecting herb-drug pairs which are less likely to interact.
Clinically-relevant chemotherapy interactions with complementary and alternative medicines in patients with cancer.
- Medicine, BiologyRecent patents on food, nutrition & agriculture
- 2010
Clinicians should be vigilant when treating cancer patients who take CAMs with concurrent chemotherapy since they face a high risk of HDIs, which can be minimized or avoided by selecting herb-drug pairs which are less likely to interact.
Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy.
- Medicine, BiologyJournal of geriatric oncology
- 2014
Phenytoin toxicity in a patient receiving 5-fluorouracil-based chemotherapy for metastatic colorectal cancer.
- MedicineCurrent oncology
- 2011
A patient with metastatic colorectal cancer who developed phenytoin toxicity after treatment with 5fu is described, consistent with a high probability of an interaction resulting in clinical symptoms and signs of pheny toin toxicity.
Standardization of the infusion sequence of antineoplastic drugs used in the treatment of breast and colorectal cancers
- Medicine, BiologyEinstein
- 2018
The infusion order of antineoplastic agents of the main therapeutic protocols used in the treatment of colorectal and breast cancer which are used in a tertiary hospital is evaluated, identifying possible interactions dependent on the infusion sequence.
Choice of antiepileptic drugs affects the outcome in cancer patients with seizures
- Medicine, PsychologyClinical and Translational Oncology
- 2018
Patients with primary or metastatic brain tumors have the same overall survival with or without seizures, however, patients with seizures not treated with antiepileptics exhibit worse overall survival.
References
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The potential interactions between AEDs and chemotherapy should be anticipated and appropriate proactive adjustments implemented, and gabapentin and levetiracetam show the most promise in treating epileptic seizures in patients with brain tumors.
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Physicians prescribing AEDs to patients with epilepsy must, therefore, be aware of the potential for drug interactions and the effects (pharmacokinetic and pharmacodynamic) that can occur both during combination therapy and on drug discontinuation.
Clinically relevant drug interactions with antiepileptic drugs.
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Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs), and pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy.
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By understanding the mechanisms of drug interactions, the pharmacist can play a key role in patient care by anticipating and preventing AED drug interactions.
Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs
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Drug-drug interactions in oncology: why are they important and can they be minimized?
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