Drug interactions between chemotherapeutic regimens and antiepileptics.

@article{Yap2008DrugIB,
  title={Drug interactions between chemotherapeutic regimens and antiepileptics.},
  author={Kevin Yi-Lwern Yap and Wai Keung Chui and Alexandre Chan},
  journal={Clinical therapeutics},
  year={2008},
  volume={30 8},
  pages={
          1385-407
        }
}

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References

SHOWING 1-10 OF 130 REFERENCES

Treating seizures in patients with brain tumors: Drug interactions between antiepileptic and chemotherapeutic agents.

The potential interactions between AEDs and chemotherapy should be anticipated and appropriate proactive adjustments implemented, and gabapentin and levetiracetam show the most promise in treating epileptic seizures in patients with brain tumors.

The Importance of Drug Interactions in Epilepsy Therapy

Physicians prescribing AEDs to patients with epilepsy must, therefore, be aware of the potential for drug interactions and the effects (pharmacokinetic and pharmacodynamic) that can occur both during combination therapy and on drug discontinuation.

Clinically relevant drug interactions with antiepileptic drugs.

  • E. Perucca
  • Medicine, Biology
    British journal of clinical pharmacology
  • 2006
Some patients with difficult-to-treat epilepsy benefit from combination therapy with two or more antiepileptic drugs (AEDs), and pharmacodynamic interactions involving AEDs have not been well characterized, but their understanding is important for a more rational approach to combination therapy.

Drug interactions in oncology.

A Mechanistic Approach to Antiepileptic Drug Interactions

  • G. Anderson
  • Biology, Medicine
    The Annals of pharmacotherapy
  • 1998
By understanding the mechanisms of drug interactions, the pharmacist can play a key role in patient care by anticipating and preventing AED drug interactions.

Drug-drug interactions in oncology: why are they important and can they be minimized?

...