Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine.

@article{Lampen1996DrugIA,
  title={Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine.},
  author={A. Lampen and Uwe Christians and Augustinus Bader and Ingelore Hackbarth and K. F. Sewing},
  journal={Pharmacology},
  year={1996},
  volume={52 3},
  pages={159-68}
}
The undecapeptide ciclosporin is used as immunosuppressant after organ transplantation and for therapy of immune diseases. Low and variable bioavailability of ciclosporin has been attributed to its metabolism in the small intestine. The aim of the present study was to investigate drug interactions and interindividual variability of ciclosporin metabolism in the small intestine. Ciclosporin metabolism was studied in vitro using microsomes isolated from the small intestine of humans and pigs. The… CONTINUE READING