Drug interaction potential of soy extract and Panax ginseng.

  title={Drug interaction potential of soy extract and Panax ginseng.},
  author={Gail D. Anderson and Gina Rosito and Michael A Mohustsy and Gary W. Elmer},
  journal={Journal of clinical pharmacology},
  volume={43 6},
To determine if soy extract or Panax ginseng increases the urinary excretion of the 6-beta-hydroxycortisol/cortisol ratio as a marker of cytochrome P450 (CYP) 3A enzyme induction, subjects received a soy extract containing 50 mg isoflavones twice daily (n = 20) or Panax ginseng 100 mg standardized to 4% ginsenosides twice daily (n = 20) for 14 days. Neither Panax ginseng nor soy extract significantly altered the urinary 6-beta-OH-cortisol/cortisol ratio, suggesting that unlike St. John's wort… CONTINUE READING
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