Drug-inducible synergistic gene silencing with multiple small hairpin RNA molecules for gene function study in animal model

Abstract

Gene targeting is a critical tool for construction of disease models. However, the application of traditional homologous recombination-mediated gene knockout technology is limited by the absence of rapid frequency-guaranteed targeting methods. Although conventional small hairpin RNA (shRNA)-mediated gene silencing offers an alternative for gene targeting… (More)
DOI: 10.1007/s11248-014-9841-9

Topics

4 Figures and Tables

Cite this paper

@inproceedings{Ying2014DruginducibleSG, title={Drug-inducible synergistic gene silencing with multiple small hairpin RNA molecules for gene function study in animal model}, author={Ming Ying and Guangfeng Chen and Yu Qiu and Xiujuan Shi and Chen Zhang and Qiuke Wang and Shuzhang Yang and Lixia Lu and Qionglan Yuan and Guotong Xu and Zibing Jin and Qiang Wu and Xiaoqing Liu}, booktitle={Transgenic Research}, year={2014} }