Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

@article{Begriche2011DruginducedTO,
  title={Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.},
  author={Karima Begriche and J. -P. Massart and M T Robin and Annie Borgne-Sanchez and Bernard Fromenty},
  journal={Journal of hepatology},
  year={2011},
  volume={54 4},
  pages={773-94}
}
Numerous investigations have shown that mitochondrial dysfunction is a major mechanism of drug-induced liver injury, which involves the parent drug or a reactive metabolite generated through cytochromes P450. Depending of their nature and their severity, the mitochondrial alterations are able to induce mild to fulminant hepatic cytolysis and steatosis (lipid accumulation), which can have different clinical and pathological features. Microvesicular steatosis, a potentially severe liver lesion… CONTINUE READING
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Mitochondrial dysfunction in nonalcoholic steatohepatitis (NASH): are there drugs able to improve it

  • K Begriche, L Knockaert, J Massart, MA Robin, B. Fromenty
  • Drug Discov Today Dis Mech 2009;6:e11–e23
  • 2009
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