Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development?

@article{Holbrook2009DrugIS,
  title={Drug induced shortening of the QT/QTc interval: an emerging safety issue warranting further modelling and evaluation in drug research and development?},
  author={Mark Holbrook and Marek Malik and Rashmi R Shah and J G Valentin},
  journal={Journal of pharmacological and toxicological methods},
  year={2009},
  volume={59 1},
  pages={21-8}
}
INTRODUCTION A session dedicated to the issue of drug-induced QT and/or QTc interval (QT/QTc) shortening of the electrocardiogram (ECG) was held at the 2007 Safety Pharmacology Society (SPS) meeting in Edinburgh. METHODS The session included a presentation on the results of a cross company survey on QT/QTc-shortening, a podium debate with speakers arguing "for" and "against" QT/QTc shortening being a safety issue and a panel discussion with the audience. RESULTS Compared to QT/QTc… CONTINUE READING

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