Drug-induced prolongation of the QT interval.

@article{Roden2004DruginducedPO,
  title={Drug-induced prolongation of the QT interval.},
  author={Dan M. Roden},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 10},
  pages={
          1013-22
        }
}
  • D. Roden
  • Published 17 June 2004
  • Medicine
  • The New England journal of medicine
The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or torsade de pointes, a condition that can be fatal. This review summarizes the current knowledge about molecular and clinical predictors of drug-induced QT-interval prolongation and torsade de pointes and discusses how new molecular predictors of drug action might be incorporated into drug-development programs and… 
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A case of extreme QT interval prolongation in association with drug therapy and the measures required to treat it is described.
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During the past few years, many drugs have been removed from the market or required to include “black box” warnings on their labels because of the potential for QT-interval prolongation.
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The molecular and cellular mechanisms underlying this acquired or drug-induced form of long QT syndrome are summarized, approaches to the analysis of a role for DNA variants in the mediation of individual susceptibility are described, and it is proposed that these concepts may be generalizable to common acquired arrhythmias.
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[Proarrhythmic adverse effects of nonarrhythmic drugs].
TLDR
During drug prescription, it is necessary to monitor QTc with regular ECGs and end of drug administration followed by monitoring of the patient according to the individual risk for TdP.
Magnitude of QT prolongation associated with a higher risk of Torsades de Pointes
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Values inferred from a population that predict a stronger potential for drug induced TdP are identified.
QT interval prolongation associated with venlafaxine administration.
Drug-Induced QT Prolongation
TLDR
It is imperative that the clinician be aware of which drugs commonly used in the perioperative setting may cause QT prolongation as well as the unique treatments for management of torsades de pointes beyond standard resuscitative measures.
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