Drug-induced prolongation of the QT interval.

@article{Roden2004DruginducedPO,
  title={Drug-induced prolongation of the QT interval.},
  author={Dan M. Roden},
  journal={The New England journal of medicine},
  year={2004},
  volume={350 10},
  pages={
          1013-22
        }
}
  • Dan M. Roden
  • Published 2004
  • Medicine
  • The New England journal of medicine
  • The single most common cause of the withdrawal or restriction of the use of marketed drugs has been QT-interval prolongation associated with polymorphic ventricular tachycardia, or torsade de pointes, a condition that can be fatal. This review summarizes the current knowledge about molecular and clinical predictors of drug-induced QT-interval prolongation and torsade de pointes and discusses how new molecular predictors of drug action might be incorporated into drug-development programs and… CONTINUE READING

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