Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity.

@article{Shah2002DruginducedPO,
  title={Drug-induced prolongation of the QT interval: regulatory dilemmas and implications for approval and labelling of a new chemical entity.},
  author={Rashmi R Shah},
  journal={Fundamental & clinical pharmacology},
  year={2002},
  volume={16 2},
  pages={147-56}
}
  • Rashmi R Shah
  • Published 2002 in Fundamental & clinical pharmacology
QT interval of the electrocardiogram (ECG) reflects the duration of the ventricular action potential. It is prolonged usually when there is delayed repolarisation due to diminished outward potassium current during phase 2 and 3 of the action potential. Clinically, it is an important pharmacological effect of a drug. This effect, when exerted in a carefully controlled manner, is the primary pharmacological mechanism by which class III anti-arrhythmic drugs exert their beneficial effect. However… CONTINUE READING

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