Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles

@article{Terland1999DruginducedPC,
  title={Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles},
  author={Ole Terland and Torgeir Flatmark},
  journal={Neuropharmacology},
  year={1999},
  volume={38},
  pages={879-882}
}
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Energy-dependent accumulation of calcium antagonists in catecholamine storage vesicles.
Pharmacological involvement of the calcium channel blocker flunarizine in dopamine transmission at the striatum.
Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine
TLDR
It is suggested that cinnarizine improves the haloperidol induced brain oxidative stress and impairment of learning and memory in the water maze test in mice.
Effect of Verapamil, Cinnarizine and Memantine on Maximal Electroshock, Picrotoxin, and Pilocarpine-Induced Seizure Models in Albino Mice
TLDR
Assessment of effects of verapamil, cinnarizine and memantine on experimentally induced convulsions in albino mice found the drug potentiated seizure occurrence in pilocarpine model.
Modulation of Visceral Nociception, Inflammation and Gastric Mucosal Injury by Cinnarizine
TLDR
It is suggested that cinnarizine exerts anti-inflammatory, antinociceptive and gastric protective properties and is likely to involve adenosine receptors and KATP channels.
LC-MS/MS method development and validation of an antihistaminic, calcium channel blocker, di-phenyl-methyl-piperazine group containing cinnarizine in human plasma with an application to BA/BE studies in Indian volunteer
TLDR
T attempts were made to develop and validate a bioanalytical method for the determination and quantitation of the cinnarizine in human plasma by liquid chromatography-mass spectrometric method and the developed method was also applied to analyse the plasma samples of healthy human volunteers obtained from a comparative pharmacokinetic study of cinnARizine 25mg tablet dosage forms.
Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice
Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells
TLDR
It is concluded that cinnarizine inhibits, by two mechanisms, pressure-induced currents that are sensitive to charybdotoxin and Ca2+.
Three-dimensional hydrogen-bonded framework structures in flunarizinium nicotinate and flunarizinediium bis(4-toluenesulfonate) dihydrate.
TLDR
The structures of two salts of flunarizine, namely 1-bis[ (4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine-1,4-diium bis(4-methylbenzenesulfonate) dihydrate, are reported and Comparisons are made with some related structures.
Neuroprotective Strategies in Parkinson’s Disease
TLDR
In spite of the extensive studies performed on postmortem substantia nigra from Parkinson’s disease patients, these studies have demonstrated that, at the time of death, a cascade of events had been initiated that may contribute to the demise of the melanin-containing nigro-striatal dopamine neurons.
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