Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.

Abstract

Fever, lymphadenopathy, exfoliative dermatitis, and evidence of drug-induced liver injury developed in a 16-year-old girl three weeks after beginning therapy with phenytoin and phenobarbital. This clinical syndrome can be caused by either of these structurally related drugs but has been more frequently attributed to phenytoin. In vitro studies disclosed… (More)
DOI: 10.1001/archinte.144.8.1677

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Cite this paper

@article{Kahn1984DruginducedLI, title={Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.}, author={H. Kahn and Guy B. Faguet and James Agee and H M Middleton}, journal={Archives of internal medicine}, year={1984}, volume={144 8}, pages={1677-9} }