Drug-induced hypothermia by 5HT1A agonists provide neuroprotection in experimental stroke: new perspectives for acute patient treatment.

@article{Johansen2014DruginducedHB,
  title={Drug-induced hypothermia by 5HT1A agonists provide neuroprotection in experimental stroke: new perspectives for acute patient treatment.},
  author={Flemming Fryd Johansen and Henrik Hasseldam and Matthias Nybro Smith and Rune Skovgaard Rasmussen},
  journal={Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year={2014},
  volume={23 10},
  pages={2879-87}
}
BACKGROUND Drug-induced hypothermia reduces brain damage in animal stroke models and is an undiscovered potential in human stroke treatment. We studied hypothermia induced by the serotonergic agonists S14671 (1-[2-(2-thenoylamino)ethyl]-4[1-(7- methoxynaphtyl)]piperazine) and ipsapirone in a rat stroke model and in man by literature meta-analysis. METHODS Rats had 60 minutes of middle cerebral artery occlusion (MCAO) and then 7 days of survival. Body temperatures were monitored for 22 hours… CONTINUE READING

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5HT(1A ) agonists may be introduced to reduce body temperatures rapidly and prepare patients for further therapeutic hypothermia .
5HT(1A ) agonists may be introduced to reduce body temperatures rapidly and prepare patients for further therapeutic hypothermia .
5HT(1A ) agonists may be introduced to reduce body temperatures rapidly and prepare patients for further therapeutic hypothermia .
5HT(1A ) agonists may be introduced to reduce body temperatures rapidly and prepare patients for further therapeutic hypothermia .
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