Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

@inproceedings{Pang2013DruginducedHE,
  title={Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin},
  author={Baoxu Pang and Xiaohang Qiao and Lennert J Janssen and Arno Velds and Tom Alphonsus Maria Groothuis and Ron H Kerkhoven and Marja Nieuwland and Huib Ovaa and Sven Rottenberg and Olaf van Tellingen and Jeroen Jwm Janssen and Peter C. Huijgens and Wilbert Zwart and Jacques Neefjes},
  booktitle={Nature communications},
  year={2013}
}
DNA topoisomerase II inhibitors are a major class of cancer chemotherapeutics, which are thought to eliminate cancer cells by inducing DNA double-strand breaks. Here we identify a novel activity for the anthracycline class of DNA topoisomerase II inhibitors: histone eviction from open chromosomal areas. We show that anthracyclines promote histone eviction irrespective of their ability to induce DNA double-strand breaks. The histone variant H2AX, which is a key component of the DNA damage… CONTINUE READING
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