Drug-induced constipation

  title={Drug-induced constipation},
  author={Rebecca L Branch and Tehreem F. Butt},
  journal={Adverse Drug Reaction Bulletin},
Constipation is a common and often debilitating adverse effect of many drugs. Here, we discuss drug classes associated with constipation, including opiates, calcium channel blockers, and anticholinergic agents, and aim to explain the underlying mechanisms involved. 
Efficacy and safety of laxatives for chronic constipation in long‐term care settings: A systematic review
There are no systematic reviews investigating the use of laxatives for chronic constipation in LTC settings and this study aims to explore the safety and efficacy of laxative in L TC patients.
Constipation in older adults: stepwise approach to keep things moving.
The prevalence of constipation increases with age and differs among settings, and in individuals 65 years of age or older in the community, the prevalence is 26% for women and 16% for men.
Diagnostic Approach to Refractory Constipation
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chronic Constipation in the Community: A National Survey of Australian Adults.
  • B. Werth, M. Fisher, K. Williams, L. Pont
  • Medicine
    Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society
  • 2020
Chronic constipation is prevalent among community-dwelling adults and various factors associated with chronic constipation have been identified, and knowledge of these factors may help health care professionals recognize individuals who are at high risk of Chronic constipation.
Diagnostic Approach to Refractory Constipation
난치성 변비 환자가 방문하였을 때 우선적으로 세밀한 병력 청취와 신체 검사를 통해 이차성 변비를 놓쳤을 가능성이 없는지를 다시 한 번 확인하여야 한다. 전통적인 완하제 복용에도 효과가 없다면 프루칼로프라이드를 고려하고 반응이 없다면 직장항문 기능 검사를 시행하여 변비의 병태생리를 평가한다. 검사 결과에 따라 약물 혹은 바이오피드백 치료를 시행하며 내과


Intractable Diarrhea from Carbamazepine
Diarrhea has been reported as an early, mild, and uncommon complication of carbamazepine therapy, necessitating discontinuation of the drug.
Drug-induced disorders of the colon
The colon is affected by a wide variety of medications. However, unlike the stomach and small intestine, the radiographic abnormalities develop over a longer time course and the clinical symptoms are
Drug-sssociated diarrhoea and constipation in older people. 2. Constipation
This second part of the review explains the mechanisms of drug-induced constipation and presents examples of drugs commonly associated with this abnormality of bowel function.
Gastrointestinal side-effects of NSAIDs in the community.
Lower-bowel symptoms were more common in the NSAID-taking cases, particularly constipation and straining, and constipation was a more common reason for stopping medication than dyspepsia, with no differences in symptoms prevalence between those taking aspirin and other NSAIDs or between individual NSAIDs.
Medication Induced Constipation and Diarrhea
The most common medications associated with constipation and diarrhea are identified as well as methods of diagnosis and treatment.
[Current aspects of the use of clozapine in the Châlons-sur-Marne Psychiatric Hospital: intestinal occlusion with clozapine].
The authors report three cases--one of them lethal--of intestinal occlusion among 30 patients treated with clozapine between 1991 and 1994 in Châlons-sur-Marne Psychiatric Hospital. The
Pathology of drug-associated gastrointestinal disease.
  • A. Price
  • Medicine
    British journal of clinical pharmacology
  • 2003
A large number of drugs have gastrointestinal side-effects of which diarrhoea or constipation, nausea and vomiting are amongst the commonest. In relatively few are there diagnostic pathological
Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use.
Antacids are likely to continue to be used for non-ulcer dyspepsia, minor episodes of heartburn (gastro-oesophageal reflux disease) and other clear indications, and clinicians should be aware of their potential drug interactions and adverse effects.
Risperidone and megacolon.
The neuro-electro-physiological mechanisms of gastro-intestinal motility are discussed and it is concluded that the risperidone-associated megacolon may be dose-related and that there should be a heightened awareness of such possible GI complication when using risperidine.
Insights into opioid action in the intestinal tract.