Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway

@article{Khan2018DruginducedCI,
  title={Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway},
  author={N. Khan and Abhishek D Garg and P. Agostinis and J. Swinnen},
  journal={Oncotarget},
  year={2018},
  volume={9},
  pages={3507 - 3518}
}
  • N. Khan, Abhishek D Garg, +1 author J. Swinnen
  • Published 2018
  • Chemistry, Medicine
  • Oncotarget
  • Malignant transformation of cells is often accompanied by the loss of the primary cilium, a protruding microtubule-based sensory organelle, suggesting that it plays an “onco-suppressive” role. Therefore, restoration of the primary cilium is being explored as a new therapeutic approach to attenuate tumor growth. Recently, several commonly used chemotherapeutic drugs have been identified to induce the primary cilium in pancreatic cancer cells. The mechanisms by which these drugs re-express the… CONTINUE READING
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