Drug-induced alterations in rat peritubular cell cytoskeleton result in proteoglycan synthesis modifications. Comparison with some intracellular signaling pathways.

@article{Thibot1999DruginducedAI,
  title={Drug-induced alterations in rat peritubular cell cytoskeleton result in proteoglycan synthesis modifications. Comparison with some intracellular signaling pathways.},
  author={B{\'e}n{\'e}dicte Thi{\'e}bot and Barbara Bilińska and Monique Langris and Jean Claude Bocquet and Serge Carreau},
  journal={Biology of the cell},
  year={1999},
  volume={91 2},
  pages={
          117-29
        }
}
The influence of phorbol myristate acetate (PMA), dibutyryl cAMP and insulin-like growth factor (IGF-1) as well as cytoskeletal disrupting drugs on morphological changes has been studied in peritubular cells isolated from immature rat testis. Morphological studies were combined with immunofluorescence investigations of cytoskeletal elements and their rearrangements by various agents. The results were correlated with modulation of proteoglycan synthesis. Peritubular cells exposed to dibutyryl… CONTINUE READING
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