Drug-induced Valvulopathy: An Update

@article{Elangbam2010DruginducedVA,
  title={Drug-induced Valvulopathy: An Update},
  author={Chandikumar S. Elangbam},
  journal={Toxicologic Pathology},
  year={2010},
  volume={38},
  pages={837 - 848}
}
Drug-induced valvulopathy is a serious liability for certain compound classes in development and for some marketed drugs intended for human use. Reports of valvulopathy led to the withdrawal of fenfluramines (anorexigens) and pergolide (antiparkinson drug) from the United States market in 1997 and 2007, respectively. The mechanism responsible for the pathogenesis of valvulopathy by these drugs is likely a result of an “off-target” effect via activation of 5-hydroxytryptamine (5-HT) 2B receptor… Expand
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