Drug-induced Otoxicity: Current Status

  title={Drug-induced Otoxicity: Current Status},
  author={V. Palomar Garc{\'i}a, F. Abdulghani Mart{\'i}nez, E. Bodet A},
  journal={Acta Oto-Laryngologica},
  pages={569 - 572}
We carried out a review of the literature published over the last 10 years on drug-induced ototoxicity by means of a Medline search using the terms 'clinical ototoxicity' for the period January 1990 to September 2000 and found 414 published articles. In order to summarize the content of these articles, we asked ourselves a series of nine questions and answered them based on the most widely-held views and those we considered of greatest interest in the articles reviewed. The questions asked were… 
5 Citations
The Contribution of Ototoxic Medications to Hearing Loss among Older Adults.
These ototoxic medications commonly used in older adults and should be considered as potentially modifiable contributors to the incidence and severity of age-related hearing loss.
Carbamazepine adverse drug reactions
Several factors should be considered for a safer use of CBZ, such as monotherapy prescription when possible, an adequate dose titration, knowledge of previous ADRs in the patient, and routine monitoring ofCBZ plasma concentrations in symptomatic patients.
The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
The aim of this study was to longitudinally analyze the effect of diabetes on hearing impairment in workers exposed to similar noise levels from 2013 to 2017 who had experienced little change in their working conditions and suggested that the risk of hearing impairment was significantly higher than that in the normal group in both ears.
Alteration of Vestibular Function in Pediatric Cochlear Implant Recipients
Minimally invasive surgery in children using around window approach or an extended round window approach with straight electrodes is desirable to preserve vestibular function after cochlear implantation.
The Association Between Glycolyzed Hemoglobin A1c and Hearing Loss in Diabetic Patients
According to HbA1c levels, the severity of diabetes can affect high to all frequencies of hearing functions negatively and the follow-up of patients with higher levels of Hb a1c should undergo audiological tests more regularly.


[The ototoxicity of cisplatin: a clinical study].
The ototoxic side effects of cisplatin are evaluated in 23 patients by a conventional and high-frequency audiogram and the ototoxicity appears to be inversely related with the patient's age, although it is difficult to draw definite conclusions.
Antioxidant therapy attenuates aminoglycoside-induced hearing loss.
  • J. Schacht
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 1999
Both hearing loss and vestibular dysfunction induced by several aminoglycosides were significantly attenuated without compromising the antibacterial efficacy of the drugs, suggesting a safe and effective way to eliminate the threat of ototoxicity of this commonly used class of antibiotics.
Cis‐Platinum ototoxicity in children
The proportion of patients who demonstrated a hearing loss increased with successive dosing as did the severity of the hearing loss, and guidelines are presented regarding the use of clinical audiometry in the screening of these pediatric oncology patients.
Salicylate attenuates gentamicin-induced ototoxicity.
  • S. Sha, J. Schacht
  • Biology, Medicine
    Laboratory investigation; a journal of technical methods and pathology
  • 1999
It is demonstrated that 2-hydroxybenzoate (salicylate), which can act as an iron chelator and antioxidant, effectively protects against gentamicin-induced hearing loss in guinea pigs and holds promise for clinical application.
The use of probenecid as a chemoprotector against cisplatin nephrotoxicity
It was concluded that probenecid may protect against CP nephrotoxicity and warrants further investigation, and its unique mechanism of action and lack of toxicity make it ideal to combine with other chemoprotectors.
Drug-Induced Tinnitus and Other Hearing Disorders
Ototoxicity, although not life-threatening, may cause considerable discomfort to patients taking ototoxic drugs, and in some cases drug discontinuation may be necessary to prevent permanent damage.
[Experimental studies of the protective effect of ginkgo biloba extract (GBE) on cisplatin-induced toxicity in rats].
The co-administration ofCDDP with GBE is beneficial to ameliorate CDDP-induced toxicity without attenuation of CDDP antitumor activity, and GBE's efficacy as a protective agent against cisplatin-induced ototoxicity is evaluated.
Ototoxicity of loop diuretics.
  • L. Rybak
  • Medicine
    Otolaryngologic clinics of North America
  • 1993
Calcium supplementation and ototoxicity in patients receiving cisplatin.
Although there was no change in serum total or ionized calcium, or serum magnesium in the calcium infusion group, no differences in hearing loss between the groups were observed and maintenance of calcium serum levels by calcium gluconate infusion did not protect against ototoxicity in those patients.
Glutathione protection against gentamicin ototoxicity depends on nutritional status