Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.

@article{Bharadwaj2012DrugHA,
  title={Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.},
  author={Mandvi Bharadwaj and Patricia T. Illing and Alex Theodossis and Anthony W. Purcell and Jamie Rossjohn and James McCluskey},
  journal={Annual review of pharmacology and toxicology},
  year={2012},
  volume={52},
  pages={401-31}
}
The human leukocyte antigen (HLA) genes are the most polymorphic in the human genome and are critical in regulating specific immunity, hence their historical discovery as "immune response" genes. HLA allotypes are also implicated in unwanted immune reactions, including drug hypersensitivity syndrome, in which small therapeutic drugs interact with antigenic peptides to drive T cell responses restricted by host HLA. Abacavir, allo-purinol, and carbamazepine are three commonly used drugs that… CONTINUE READING

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