Drug hypersensitivity: pharmacogenetics and clinical syndromes.


Severe cutaneous adverse reactions include syndromes such as drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS) and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). An important advance has been the discovery of associations between HLA alleles and many of these syndromes, including… (More)
DOI: 10.1016/j.jaci.2010.11.046

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