Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial.

  title={Drug-food interaction potential of clarithromycin, a new macrolide antimicrobial.},
  author={Song Yun Chu and Y Park and Charles Locke and Daniel P. Siewiorek Andrew Wilson and John C. Cavanaugh},
  journal={Journal of clinical pharmacology},
  volume={32 1},
To evaluate the effect of food on bioavailability, clarithromycin and 14-hydroxyclarithromycin (active metabolite) pharmacokinetics were assessed in 26 healthy adult volunteers after ingestion of a single oral 500-mg dose of clarithromycin in a fasting state (2 hours before breakfast after an overnight fast) and a nonfasting state (0.5 hours after the start of breakfast). Clarithromycin and 14-hydroxy metabolite plasma concentrations were measured using a high-performance liquid chromatographic… CONTINUE READING

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