Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody.

@article{Kuwada2007DrugEV,
  title={Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody.},
  author={Scott K. Kuwada},
  journal={Current opinion in molecular therapeutics},
  year={2007},
  volume={9 1},
  pages={92-8}
}
PDL Biopharma Inc (formerly Eos Biotechnology Inc) and Biogen Idec Inc are developing volociximab, an angiogenesis-inhibiting chimeric mAb that targets AAB1, a component protein of alpha5/beta1 integrin, for the potential treatment of solid tumors, including renal cell carcinoma. Two phase II clinical trials evaluating volociximab in solid tumors are underway. Volociximab is also under investigation for the treatment of age-related macular degeneration.