Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease.

@article{Geerts2007DrugE,
  title={Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease.},
  author={Hugo Geerts},
  journal={IDrugs : the investigational drugs journal},
  year={2007},
  volume={10 2},
  pages={
          121-33
        }
}
  • Hugo Geerts
  • Published in
    IDrugs : the investigational…
    2007
(R)-flurbiprofen, the R-enantiomer of racemic flurbiprofen, is undergoing development by Myriad Genetics Inc, under license from Encore Pharmaceuticals Inc, for the potential treatment of Alzheimer's disease (AD). Devoid of any direct cyclooxygenase inhibition, which is associated with the more toxic S-enantiomer of flurbiprofen, (R)-flurbiprofen appears to modulate gamma-secretase, the enzyme that cleaves the C-terminal portion of the malignant Abeta(1-42) peptide out of amyloid precursor… CONTINUE READING

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