Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics.

@article{Rapoport1982DrugEI,
  title={Drug entry into and distribution within brain and cerebrospinal fluid: [14C]urea pharmacokinetics.},
  author={Stanley I. Rapoport and Richard Fitzhugh and Karen D. Pettigrew and Uma Sundaram and Kikuo Ohno},
  journal={The American journal of physiology},
  year={1982},
  volume={242 3},
  pages={R339-48}
}
A four-compartment model was derived to analyze drug exchange among cerebral capillary plasma, cerebrospinal fluid (CSF), and the brain extracellular and intracellular (or bound) compartments. Equations that were derived incorporated the factor of cerebral blood flow. They were fit by nonlinear least squares to measured brain, plasma, and CSF (when available) concentrations of [14C]urea in the rat, in response to a step increase in plasma concentration, to intravenous infusion, or to a bolus… CONTINUE READING

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