Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics.

  title={Drug enterohepatic circulation and disposition: constituents of systems pharmacokinetics.},
  author={Yu Gao and Jingwei Shao and Zhou Jiang and Jianzhong Chen and Songen Gu and Suhong Yu and Zheng Sun and Lee Jia},
  journal={Drug discovery today},
  volume={19 3},
Drug disposition information constitutes a part of systems pharmacokinetics, and becomes imperative when a drug shows significant effects at its disproportionally low blood concentration. The situation could result from outweighing the parent drug in tissues over in blood and/or from its active metabolites. Fractions of certain drugs absorbed from the intestine to the systemic circulation via the portal vein can return to the intestine via the bile duct and the sphincter of Oddi - a… CONTINUE READING
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