Drug encapsulation using supercritical fluid extraction of emulsions.

  title={Drug encapsulation using supercritical fluid extraction of emulsions.},
  author={Pratibhash Chattopadhyay and Robert W. Huff and Boris Yu. Shekunov},
  journal={Journal of pharmaceutical sciences},
  volume={95 3},
The current work was aimed at evaluating a new method, supercritical fluid extraction of emulsions (SFEE), for the production of composite (e.g., polymer-drug) micro- and nanoparticles, intended for application in sustained-release drug delivery formulations. Using the proposed method, composite particles were obtained, both in a continuous or batch manner by supercritical carbon dioxide extraction of oil-in-water (o/w) emulsions. Model drugs indomethacin and ketoprofen and biodegradable… CONTINUE READING
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